Cultured human keratinocytes maintained in 30 μM Ca2+ do not form adherens junctions; however, when the extracellular Ca2+ concentration is raised to 1 mM, adherens junctions form very rapidly. The formation of a junction involves the coordinate organization of intracellular and extracellular components. Cadherins have been shown to mediate this coordinate organization. In this report we show that E-cadherin organizes the various junctional components by signalling through protein kinase C.
Lewis J.E., Jensen P.J., Johnson K.R., Wheelock M.J. (1994) E-cadherin mediates adherens junction organization through protein kinase C. Journal of Cell Science 107: 3615-3621. doi: