Submission Type

Poster

Start Date

4-26-2023

Abstract

The ketogenic diet (KD) is a high fat, low carb diet which is growing in popularity as a possible method to improve working memory and prevent alcohol use disorder (AUD). We used a mouse model where half of the mice were fed a standard diet (SD) while the other half were fed the KD. All mice experienced a 7 week drinking period where they were introduced to alcohol for 2 hours, 3 days a week. We then tested the mice in a working memory task. We modeled working memory using the Barnes maze. Mice escaped to a target hole in the maze using spatial cues. Each of the 4 trial days, a new target hole was chosen. We found no correlation between alcohol and maze performance and KD improved working memory independent of alcohol use history.

Comments

Sponsored by Allison Bechard

Share

COinS
 
Apr 26th, 12:00 AM

345 - The Effects of Alcohol and Ketogenic Diet on Working Memory in Mice

The ketogenic diet (KD) is a high fat, low carb diet which is growing in popularity as a possible method to improve working memory and prevent alcohol use disorder (AUD). We used a mouse model where half of the mice were fed a standard diet (SD) while the other half were fed the KD. All mice experienced a 7 week drinking period where they were introduced to alcohol for 2 hours, 3 days a week. We then tested the mice in a working memory task. We modeled working memory using the Barnes maze. Mice escaped to a target hole in the maze using spatial cues. Each of the 4 trial days, a new target hole was chosen. We found no correlation between alcohol and maze performance and KD improved working memory independent of alcohol use history.

 

To view the content in your browser, please download Adobe Reader or, alternately,
you may Download the file to your hard drive.

NOTE: The latest versions of Adobe Reader do not support viewing PDF files within Firefox on Mac OS and if you are using a modern (Intel) Mac, there is no official plugin for viewing PDF files within the browser window.