Microscopic investigation of reversible nanoscale surface size dependent protein conjugation

Authors

Kazushige Yokoyama, SUNY Geneseo
Hyunah Cho, SUNY Geneseo
Sean P. Cullen, SUNY Geneseo
Matthew Kowalik, SUNY Geneseo
Nicole M. Briglio, SUNY Geneseo
Harold Hoops, SUNY Geneseo
Zhouying Zhao
Michael A. Carpenter

Document Type

Article

Publication Date

2009

Abstract

Aβ1-40 coated 20 nm gold colloidal nanoparticles exhibit a reversible color change as pH is externally altered between pH 4 and 10. This reversible process may contain important information on the initial reversible step reported for the fibrillogenesis of Aβa hallmark of Alzheimer's disease). We examined this reversible color change by microscopic investigations. AFM images on graphite surfaces revealed the morphology of Aβ aggregates with gold colloids. TEM images clearly demonstrate the correspondence between spectroscopic features and conformational changes of the gold colloid. © 2009 by the authors.

Comments

© authors, Creative Commons Attribution License 4.0

Recommended Citation

Yokoyama K., Cho H., Cullen S.P., Kowalik M., Briglio N.M., Hoops H.J., Zhao Z., Carpenter M.A. (2009) Microscopic investigation of reversible nanoscale surface size dependent protein conjugation. International Journal of Molecular Sciences 10: 2348-2366. doi: 10.3390/ijms10052348

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 License.