Submission Type

Poster

Start Date

April 2020

Abstract

The adsorption of alpha-synuclein (a-syn) was studied by attempting the adsorption over the surface of nano-gold colloidal particles as a function of concentration of the a-syn. The change in surface property caused by the degree of peptide coverage was hypothesized to reflect the aggregation formation channels. As the concentration of the a-syn increased, the aggregation size had increased in a non-linear fashion. Currently, we hypothesize two different aggregation channels and one is a gradual growth and the other is a step function type of behavior which holds a certain threshold to form an aggregate.

Comments

Sponsored by Kazushige Yokoyama

Share

COinS
 
Apr 22nd, 12:00 AM

348— Establishment of peptide aggregation process

The adsorption of alpha-synuclein (a-syn) was studied by attempting the adsorption over the surface of nano-gold colloidal particles as a function of concentration of the a-syn. The change in surface property caused by the degree of peptide coverage was hypothesized to reflect the aggregation formation channels. As the concentration of the a-syn increased, the aggregation size had increased in a non-linear fashion. Currently, we hypothesize two different aggregation channels and one is a gradual growth and the other is a step function type of behavior which holds a certain threshold to form an aggregate.

 

To view the content in your browser, please download Adobe Reader or, alternately,
you may Download the file to your hard drive.

NOTE: The latest versions of Adobe Reader do not support viewing PDF files within Firefox on Mac OS and if you are using a modern (Intel) Mac, there is no official plugin for viewing PDF files within the browser window.