249— The role of the indirect basal ganglia pathway in a mouse model of repetitive circling behavior
Submission Type
Poster
Start Date
April 2021
Abstract
Repetitive behaviors are associated with a variety of disorders in humans and are diagnostic for autism spectrum disorders. Repetitive behaviors can be modeled in rodents. In our previous experiments, we have been able to reduce repetitive circling behaviors in mice using a ketogenic diet. The mechanisms behind the ketogenic diet are still under investigation. Previous investigations have indicated that the ketogenic diet plays a role in neurotransmitter functioning. This study sought to investigate the potential role of neurotransmitters in repetitive behaviors by investigating how three drugs (L-741,626, a dopamine receptor antagonist; CGS21680, an adenosine agonist; & CDPPB, a glutamate positive allosteric modulator) affected circling behavior. Circling behavior was measured using photobeam activated locomotor chambers. Individual doses of each drug as well as a “triple cocktail” consisting of all three drugs were utilized during the experiments. Results indicate that systemic injection of the single drug and triple drug cocktail were not able to reduce circling behavior.
Recommended Citation
Vaughan, Gavin and Bechard, Allison R., "249— The role of the indirect basal ganglia pathway in a mouse model of repetitive circling behavior" (2021). GREAT Day Posters. 16.
https://knightscholar.geneseo.edu/great-day-symposium/great-day-2021/posters-2021/16
Included in
249— The role of the indirect basal ganglia pathway in a mouse model of repetitive circling behavior
Repetitive behaviors are associated with a variety of disorders in humans and are diagnostic for autism spectrum disorders. Repetitive behaviors can be modeled in rodents. In our previous experiments, we have been able to reduce repetitive circling behaviors in mice using a ketogenic diet. The mechanisms behind the ketogenic diet are still under investigation. Previous investigations have indicated that the ketogenic diet plays a role in neurotransmitter functioning. This study sought to investigate the potential role of neurotransmitters in repetitive behaviors by investigating how three drugs (L-741,626, a dopamine receptor antagonist; CGS21680, an adenosine agonist; & CDPPB, a glutamate positive allosteric modulator) affected circling behavior. Circling behavior was measured using photobeam activated locomotor chambers. Individual doses of each drug as well as a “triple cocktail” consisting of all three drugs were utilized during the experiments. Results indicate that systemic injection of the single drug and triple drug cocktail were not able to reduce circling behavior.
Comments
Sponsored by Allison Bechard