Submission Type
Poster
Abstract
Ketogenic diet (KD) is a diet with high fat, moderate amount of protein and low carbohydrate. KD has been known for many therapeutic purposes, including alcohol abuse. This project focuses on how KD affects cognitive performance in mice administered alcohol. Three groups of mice were used in this study; one group was given 20% EtOH and KD, another group with only 20% EtOH, and the last group without 20% EtOH or KD which was our control group. Before the alcohol administration period began, the KD mice were fed KD for 1 week. Then, mice assigned to EtOH groups were injected intraperitoneally for 10 days in a row, and no-alcohol controls were injected with 0.1mL saline. We found that mice fed KD performed better in a test of working memory. Alcohol moderately increased latencies in the maze and beams broken in a locomotor test. No differences were found in the hippocampus following a stain that shows cell bodies.
Recommended Citation
Brahmbhatt, Dhavan, "284-Alcohol Use, Neuroinflammation, and a Ketogenic Diet in a Mouse Model of Alcohol Use" (2024). GREAT Day Posters. 81.
https://knightscholar.geneseo.edu/great-day-symposium/great-day-2024/posters-2024/81
284-Alcohol Use, Neuroinflammation, and a Ketogenic Diet in a Mouse Model of Alcohol Use
Ketogenic diet (KD) is a diet with high fat, moderate amount of protein and low carbohydrate. KD has been known for many therapeutic purposes, including alcohol abuse. This project focuses on how KD affects cognitive performance in mice administered alcohol. Three groups of mice were used in this study; one group was given 20% EtOH and KD, another group with only 20% EtOH, and the last group without 20% EtOH or KD which was our control group. Before the alcohol administration period began, the KD mice were fed KD for 1 week. Then, mice assigned to EtOH groups were injected intraperitoneally for 10 days in a row, and no-alcohol controls were injected with 0.1mL saline. We found that mice fed KD performed better in a test of working memory. Alcohol moderately increased latencies in the maze and beams broken in a locomotor test. No differences were found in the hippocampus following a stain that shows cell bodies.