Submission Type
Poster
Abstract
The ketogenic diet (KD) has long been used to control epilepsy, but more recently has also been shown to improve symptoms of Autism Spectrum Disorder (ASD). ASD is a highly prevalent disorder, characterized partially by repetitive behavior. Genetics, environmental conditions, and resultant injury to the brain, have been linked to an increased risk for ASD. KD is thought to work as an anti-inflammatory and has been shown to decrease repetitive behavior in a mouse model of ASD; but, how KD works within ASD is not well understood. This project works with a mouse model of ASD to determine if early KD intervention prevents the development of ASD behaviors in mice, and explores if glial fibrillary acidic protein (GFAP), a marker of inflammation, may be how KD helps ASD. It is hypothesized that mice that develop repetitive behavior will show altered expression of GFAP that will be restored by KD intervention.
Recommended Citation
Azurin, Sophia, "319-Characterization of Motor Performance in a Mouse Model of Autism Fed a Ketogenic Diet in Early Adolescence" (2024). GREAT Day Posters. 88.
https://knightscholar.geneseo.edu/great-day-symposium/great-day-2024/posters-2024/88
319-Characterization of Motor Performance in a Mouse Model of Autism Fed a Ketogenic Diet in Early Adolescence
The ketogenic diet (KD) has long been used to control epilepsy, but more recently has also been shown to improve symptoms of Autism Spectrum Disorder (ASD). ASD is a highly prevalent disorder, characterized partially by repetitive behavior. Genetics, environmental conditions, and resultant injury to the brain, have been linked to an increased risk for ASD. KD is thought to work as an anti-inflammatory and has been shown to decrease repetitive behavior in a mouse model of ASD; but, how KD works within ASD is not well understood. This project works with a mouse model of ASD to determine if early KD intervention prevents the development of ASD behaviors in mice, and explores if glial fibrillary acidic protein (GFAP), a marker of inflammation, may be how KD helps ASD. It is hypothesized that mice that develop repetitive behavior will show altered expression of GFAP that will be restored by KD intervention.