Submission Type
Poster
Abstract
We synthesized and characterized a ytterbium- and thulium-codoped dicalcium phosphate cement with potential therapeutic applications. Critical bone fractures pose a significant challenge to healthcare, often requiring invasive autografting due to a lack of effective alternatives. Calcium phosphate cements have arisen as a possible alternative, as they mimic the chemical composition of bones and promote healing. Among calcium phosphate cements, dicalcium phosphate cements, particularly monetite, are advantaged in resorption rate and osteoinductivity. The mechanical properties of monetite, however, pose an issue for its implementation as a bone replacement material. Recent research explores rare earth metal doping as a means to enhance the performance of calcium phosphate cements. To test this, we manufactured a ytterbium- and thulium-codoped dicalcium phosphate cement by preparing codoped β-tricalcium phosphate and reacting it with monocalcium phosphate monohydrate in the presence of water. The synthesized codoped dicalcium phosphate cement was then characterized with fourier-transform infrared spectroscopy, x-ray diffraction, and scanning electron microscopy. The cement’s final setting time was determined using a Vicat needle apparatus, while photoluminescence spectrometry was used to monitor upconversion luminescent emissions caused by ytterbium/thulium codoping. The optimization of lanthanide doped dicalcium phosphate cements may allow for a resorbable, injectable, and theragnosticly useful cement to enhance the fracture healing process.
Recommended Citation
Miller, Milo and Trojanowski, Trinity, "046 - Synthesis and Analysis of a Ytterbium- and Thulium-Codoped Upconverting Dicalcium Phosphate Cement for Potential Use as a Bone Defect Filler" (2025). GREAT Day Posters. 15.
https://knightscholar.geneseo.edu/great-day-symposium/great-day-2025/posters-2025/15
046 - Synthesis and Analysis of a Ytterbium- and Thulium-Codoped Upconverting Dicalcium Phosphate Cement for Potential Use as a Bone Defect Filler
We synthesized and characterized a ytterbium- and thulium-codoped dicalcium phosphate cement with potential therapeutic applications. Critical bone fractures pose a significant challenge to healthcare, often requiring invasive autografting due to a lack of effective alternatives. Calcium phosphate cements have arisen as a possible alternative, as they mimic the chemical composition of bones and promote healing. Among calcium phosphate cements, dicalcium phosphate cements, particularly monetite, are advantaged in resorption rate and osteoinductivity. The mechanical properties of monetite, however, pose an issue for its implementation as a bone replacement material. Recent research explores rare earth metal doping as a means to enhance the performance of calcium phosphate cements. To test this, we manufactured a ytterbium- and thulium-codoped dicalcium phosphate cement by preparing codoped β-tricalcium phosphate and reacting it with monocalcium phosphate monohydrate in the presence of water. The synthesized codoped dicalcium phosphate cement was then characterized with fourier-transform infrared spectroscopy, x-ray diffraction, and scanning electron microscopy. The cement’s final setting time was determined using a Vicat needle apparatus, while photoluminescence spectrometry was used to monitor upconversion luminescent emissions caused by ytterbium/thulium codoping. The optimization of lanthanide doped dicalcium phosphate cements may allow for a resorbable, injectable, and theragnosticly useful cement to enhance the fracture healing process.
Comments
Sponsored by Barnabas Gikonyo