Document Type

Poster

Publication Date

4-17-2019

Abstract

With an ever-increasing average human lifespan, a growing area of research is concerned with debilitating neurodegenerative diseases. Parkinson’s and Huntington’s disease (HD) are neurodegenerative disorder in which degradation of cells is observed. Thus, development of useful and sensitive measures of motor coordination in animal models is paramount in advancing basic research.

In this preliminary study, C57/BLJ mice were tested in novel paw reaching chambers used to evaluate fine motor coordination. The same animals were also tested in a grip-strength apparatus, a well-established device designed to measure muscle strength. Measures from both tests will then be correlated to determine differences in performance between males and females in these two tasks as the mice age. Future research will use these tasks to evaluate changes in transgenic knock-in models of HD compared to the established baseline of motor function.

Creative Commons License

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.

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