Abstract
A Ketogenic diet (KD) is a diet with high fat, moderate amounts of protein, and low carbohydrate. KD has been known for many therapeutic purposes. This project focuses on the study of how KD affects cognitive performance in mice administered alcohol. Three groups of mice were used in this study, two groups were injected with 20% alcohol (EtOH) and one group was no-alcohol controls. Before the alcohol administration period began, the KD mice were fed KD for 1 week. Then, mice assigned to EtOH groups were injected intraperitoneally for 10 days in a row, while no-alcohol controls were not injected with anything. It is expected that mice that were injected with alcohol will have lower cognitive performance in a test of working memory and higher GFAP expression in the hippocampus compared to no-alcohol controls, and KD will rescue cognitive performance and reduce GFAP.
Recommended Citation
Brahmbhatt, Dhavan
(2025)
"Alcohol Use, Neuroinflammation, and a Ketogenic Diet in a Mouse Model of Alcohol Use,"
Proceedings of GREAT Day: Vol. 16, Article 9.
Available at:
https://knightscholar.geneseo.edu/proceedings-of-great-day/vol16/iss1/9