The anticancer affects of Tumor Necrosis Factor Alpha and Tamoxifen have been widely recognized. Our preliminary experiments have revealed that HTB-26 breast cancer cells are nonresponsive to Tamoxifen due to low expression of the estrogen receptor. Other studies have shown that the 5 Azacytidine can stimulate the presence of the estrogen receptor. Experiments were carried out in an attempt to re-stimulate the sensitivity of breast cancer cells to Tamoxifen and measure the death-inducing properities of Tumor Necrosis Factor Alpha. Ideal results would include an increased susceptibility of Tamoxifen after a 5- Azacytidine treatment along with an increase in apoptosis, or programmed cell death.
Roloff, Gregory and Bosch, Jessica
"Investigation into the Combined Affects of Tumor Necrosis Factor-Alpha, Tamoxifen and 5-Azacytidine on HTB-26 Breast Cancer Cells,"
Proceedings of GREAT Day: Vol. 2011
, Article 5.
Available at: https://knightscholar.geneseo.edu/proceedings-of-great-day/vol2011/iss1/5